Cetapin XR 1000mg (Metformin) 150's

Cetapin general information

What is Cetapin used for?

Cetapin XR tablets 1000mg are an oral diabetes medication that is used to control blood sugar levels in people with type-2 diabetes mellitus (also called non-insulin dependent diabetes or maturity onset diabetes) who are unable to achieve adequate glycaemic control (normal blood sugar levels) with diet and exercise alone, which is a particular problem in overweight people.  Cetapin XR tablets 1000mg can be used as first time treatment for newly diagnosed diabetics, or for patients who are not responding to an alternative medication, and can be used either alone or in combination with another oral antihyperglycaemic medication (lowers blood sugar).  In some cases Cetapin XR is used in conjunction with insulin in type 1 diabetes (also called insulin -dependent diabetes), where insulin alone is not enough to control blood sugar levels.  Cetapin XR tablets 1000mg are also associated with stable body weight or even some weight loss.

How does Cetapin work?

Cetapin XR tablets 1000mg contain the active ingredient metformin hydrochloride, which is an oral antihyperglycaemic medication belonging to the biguanide group of drugs.  Metformin in Cetapin XR tablets 1000mg controls blood glucose (sugar) by lowering levels of glucose after a meal (posprandial) as well as keeping levels normal between meals (basal levels), by helping the body respond to insulin without increasing insulin production.  Metformin in Cetapin XR tablets 1000mg works using three different mechanisms: decreasing glucose production in the liver, which is normally switched off when blood glucose levels are high enough; increasing sensitivity to insulin in fat and muscle tissue, where excess glucose is removed from the blood and stored; reducing absorption of glucose by the intestines from the diet.  Maintaining glycaemic control with Cetapin XR tablets 1000mg reduces risk of serious health complications associated with diabetes, including diabetic retinopathy (damage to the retina in the eye with loss of vision), diabetic neuropathy (nerve damage) and diabetic nephropathy (kidney damage). 

What does Cetapin contain?

Cetapin XR tablets 1000mg contain the active ingredient metformin hydrochloride, an oral antihyperglycaemic medication used to control blood sugar levels in people with type-2 diabetes mellitus. 

Treating type 2 diabetes with Cetapin

Cetapin XR tablets 1000mg contain Metformin, which is an oral antihyperglycaemic medication that is used to control blood sugar levels in people with type-2 diabetes mellitus (also called non insulin-dependent diabetes or maturity onset diabetes) who are unable to achieve adequate glycaemic control (normal blood sugar levels) with diet and exercise alone, which is a particular problem in overweight people.  Metformin in Cetapin XR tablets 1000mg lowers blood sugar after a meal (posprandial) as well as keeping levels normal between meals (basal levels), by helping the body respond to insulin without increasing insulin production, using three different mechanisms: decreasing glucose production in the liver, which is normally switched off when blood glucose levels are high enough; increasing sensitivity to insulin in fat and muscle tissue, where excess glucose is removed from the blood and stored; reducing absorption of glucose by the intestines form the diet.  Maintaining glycaemic control with Cetapin XR tablets 1000mg reduces risk of serious health complications associated with diabetes, including diabetic retinopathy (damage to the retina in the eye with loss of vision), diabetic neuropathy (nerve damage) and diabetic nephropathy (kidney damage).  Cetapin XR tablets 1000mg are also associated with stable body weight or even some weight loss.

What are the side effects of Cetapin?

The most commonly reported side effects when taking Cetapin XR tablets 1000mg include: gastrointestinal symptoms (such as diarrhoea, nausea, vomiting) which are usually mild and resolve spontaneously during continued treatment, metallic taste in the mouth and skin rash.  A rare and potentially life threatening side effect is lactic acidosis (a build-up of lactic acid in the blood) that can occur due to accumulation of metformin, particularly if you are taking high doses of metformin above 2000mg per day, have kidney problems, drink excessive amounts of alcohol, are elderly.

When should Cetapin not be used?

You should not use Cetapin XR tablets 1000mg if you:

• are allergic to metformin or any other biguanide or any ingredients in Cetapin 1000mg
• are pregnant or are breastfeeding without discussion with your doctor
• have liver or kidney disease
• have a conditions affecting renal function, like dehydration, severe infection or shock
• have diabetic ketoacidosis, diabetic precoma
• have acute or chronic disease which may cause tissue hypoxia such as heart failure, recent myocardial infarction, respiratory failure, pulmonary embolism, shock, acute significant blood loss, sepsis, gangrene, pancreatitis
• have a history of lactic acidosis
• have a problem with alcohol
• are undergoing radiological treatment with intravascular iodinated contrast agents which may lead to renal failure, resulting in metformin accumulation and a risk of lactic acidosis
• are taking medications that may interact with Cetapin including: cimetidine for reflux and ulcers, medications for high blood pressure and heart conditions like nifedipine, beta-blockers, diuretics, other diabetes medications like sulfonylureas, corticosteroids such as prednisone, cortisone, anticoagulants

What medications interact with Cetapin?

Several medications interact with Cetapin and should either not be taken while you are taking Cetapin or only after discussion and instruction from your doctor:

• Drugs that cause a serious reaction or increase side effects with Cetapin: other diabetes medications like sulfonylureas, ACE inhibitors for high blood pressure, corticosteroids such as prednisone, cortisone
• Drugs that affect Cetapin: cimetidine for reflux and ulcers, medications for high blood pressure and heart conditions like nifedipine, beta-blockers, diuretics, thyroid medicines
• Drugs that are affected by Cetapin: anticoagulants

How should Cetapin be taken?

You should take your Cetapin XR tablets 1000mg with a glass of water and with food.  The dose you take and how often should be as recommended by your doctor.  The usual starting dose is one tablet once, twice or 3 times daily during or immediately after a meal, to reduce stomach effects.  You will have your blood sugar levels monitored and your dose may be adjusted after a few weeks, depending on how well your blood sugar levels are controlled.  You should continue to take your Cetapin XR tablets 1000mg for as long as recommended by your doctor, which may be for long periods.

How long should you take Cetapin?

You should continue to take your Cetapin XR tablets 1000mg for as long as recommended by your doctor, which may be for long periods.

Missed dose of Cetapin

If you miss a dose of Cetapin XR tablets 1000mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Cetapin be stored?

You should store your Cetapin below 25°C in a cool dry place.